MS & Detection Techniques Series

Mass Spectrometry and Hyphenation

A deep dive into mass spectrometry covering ionization methods, analyzers, data interpretation, and fragmentation—teaching how molecular structure guides technique choice and how to apply these principles in tandem MS.
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  • 5+ Hours

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    MS & Detection Techniques Series

    Course Description

    Embark on a comprehensive exploration of mass spectrometry and its diverse applications. Delve into the intricacies of different ionization techniques and analyzers, with a focal point on utilizing the molecule’s structure to guide users towards the appropriate ionization and sample introduction techniques.

    The course underscores the significance of mastering the correct nomenclature and performance criteria for mass spectrometers, fostering clear communication in experimental design and result dissemination. Participants will gain invaluable insights into data interpretation strategies, accompanied by simple mechanistic approaches to fragmentation.

    The curriculum seamlessly integrates these principles with fundamental tandem mass spectrometry concepts, fostering an understanding of the behavior of odd and even electron species.
    MS & Detection Techniques Series

    Course Highlights

    • In-depth exploration of various ionization techniques in mass spectrometry

    • Comprehensive overview of different analyzers used in mass spectrometry

    • Utilization of molecular structure for guiding ionization and sample introduction strategies

    • Emphasis on mastering nomenclature and performance criteria for effective communication

    • Strategies for data interpretation and basic mechanistic approaches to fragmentation

    • Integration of principles into tandem mass spectrometry, focusing on odd and even electron species behavior

    About the instructor

    John Langley

    Professor John Langley is an expert in mass spectrometry and chromatography, researching complex systems through the application and development of different analytical approaches. John has over 130 peer-reviewed publications (more than 150 in Google Scholar) and an H-index of 35 and has published in over 30 leading scientific journals, reflecting the multidisciplinary nature of the applications of his research activity.
    John has 40 years of experience in the academic sector and specializes in the application of separation science and mass spectrometry as a research tool for chemistry, chemical biology, and oilfield chemistry, addressing complexity and probing new research areas. Specific interests are the application of hyphenated approaches (GC-MS, GCxGC-MS, HPLC-MS, LCxLC-IMS-MS, MS/MS, SFC-MS and SFC-FID).
    John has 30 years of sustained research funding with RCUK and industry, (including AZ, BP, GSK, Innospec, and Syngenta) and was awarded the Chromatographic Society Jubilee Medal 2024 and the British Mass Spectrometry Society Medal 2021.

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